![]() ![]() By using the dpa congenic strain (dpa CG) whose genetic background is identical to BALB except that the gene(s) controlling gurmarin sensitivity are derived from C57BL, we previously found that genetically-elevated gurmarin sensitivity in dpa CG mice, confirmed by using behavioral response and whole CT nerve response analyses, was linked to a greater taste cell population co-expressing sweet taste receptors and a G(alpha)- protein, G(alpha)-gustducin. In C57BL mice, sweet-responsive fibers of the chorda tympani (CT) nerve can be divided into two distinct populations, gurmarin-sensitive (GS) and gurmarin-insensitive (GI) types, suggesting the existence of two distinct reception pathways for sweet taste responses. In mice, gurmarin sensitivity differs among strains with gurmarin-sensitive C57BL and gurmarin-poorly-sensitive BALB strains. The peptide gurmarin is a selective sweet response inhibitor for rodents. The mouse strain difference in the Gur inhibition of sweet responses of the CT nerve may not be associated with polymorphisms Mice, 129X1/Sv mice exhibited significant inhibition of CT responses to various sweet compounds by Gur. The results indicated that unlike non-taster BALB/c mice but similar to taster C57BL/6 To investigate this possibility, we examined the effect of Gur in another Tas1r3 non-taster strain, 129X1/Sv mice. Gene, Sac (Tas1r3) (taster genotype for C57BL/6 and non-taster genotype for BALB/c mice), suggesting that polymorphisms in the gene may accountįor differential sensitivity to Gur. These two mouse strains possess different alleles of the sweet receptor Mice, but only slightly, if at all, in BALB/c mice. The inhibitory effect of Gur is clearly observed in C57BL/6 In mice, the sweet-suppressing effect of Gur differs among strains. Gurmarin (Gur) is a peptide that selectively inhibits responses of the chorda tympani (CT) nerve to sweet compounds in rodents. ![]()
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